New York University School of Medicine
Dr. Costa has been working in the area of epigenetics and cancer for over 20 years. He has studied how carcinogenic metals affect the epigenetic program through inhibition of histone demethylases. In particular, Dr. Costa has studied how Arsenic, Nickel and Chromate alter histone posttranslational modifications in chromatin using cell culture and in human PBMCs. Dr. Costa has also conducted ChIP-Seq using several histone marks and RNA-Seq following carcinogenic metal treatment of cells. He has been working on the mechanism of metal carcinogenesis for over 35 years.
Environmental Medicine, Genotoxicity, Toxicology, Pharmacology,Oncology