T G Borovskaya
Tomsk Cancer Research Institute, Russia
Title: Experimental study of long-term effects of different drugs on female reproduction system and posterity: Pharmacological way to reduce
Biography
Biography: T G Borovskaya
Abstract
At present there are oncologic diseases that are considered to be fundamentally curable, but with chemotherapeutic agents only. Effectiveness of treatment of these patients includes keeping their reproductive function actual. The aim of this work was to study experimentally the reproductive status of female rats depending on cytostatic impact of drugs. The objective also included a comparative assessment of toxic effects of anti-neoblastoma agents on posterity, as well as investigating the ways of pharmacological correction of pathological changes in posterity. Platidiam, carboplatin, epirubicin, etoposide, paclitaxel were administered to female rats in a maximally tolerated dose. It was obtained that the earliest menopause can be expected after administration of anthracycline antibiotic. Fertility was significantly decreased after application of second-generation platinum compound and inhibitor of topo-isomerase activity. The largest number of pathological changes in viable posterity was observed after administration of paclitaxel. Among the drugs correction of posterity the uromitexan, glutoxim and kortagen are considered.
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