Xin Wang
Fourth Military Medical University, China
Title: Redox regulation in health and disease: Novel hypothesis
Biography
Biography: Xin Wang
Abstract
In view of the critical role of redox system in numerous physiological and pathophysiological processes, it is important to clearly understand the constitution and regulatory mechanism of redox system. In this work, we will systematically review the current data detailing the reactive oxygen species (ROS), enzymatic and non-enzymatic antioxidants and redox sensitive transcription factors and we give a brief description of redox-exerted epigenetic and post-translational regulation. We propose that the redox system functions as a “Redox Chain”, consisting of “ROS-generating Enzyme Chain”, “Combined Antioxidant Chain” and “Transcription Factor Chain”. We suggest that redoxomic techniques should be extensively applied to understand the biological effects of redox alterations in a more integrated way. A stable and standardized “redox index” is urgently needed for the evaluation of the general redox status. We suggest that for the redox intervention of an individual, an individualized assessment of the redox status in the body should be conducted. The strategy of intervention is to maintain general redox balance rather than to conduct simple pro-oxidant or anti-oxidative interventions. These findings provide valuable new insights into redox system and open up new paths for the control of redox-related disorders.